• Nanobiosensors

    In 2000, our laboratory developed the first antibody-based nanobiosensor for monitoring biochemical species in a single living human cell [Nature Biotechnology, 18: 764-767 (2000)]. Various nanobiosensors were later developed for monitoring intracellular parameters...

  • SERS Molecular Probes

    In 1994 our laboratory first introduced a new modality for nucleic acid bioassays using SERS detection [Analytical Chemistry, 66, 3379 (1994)]. We further extended the new family of SERS gene probes with the development of ‘Molecular Sentinels’ and Plasmonic Coupling Interference (PCI)...

  • SERS Plasmonic Chips

    In 1984, our laboratory first reported the general applicability of SERS as an analytical technique [Analytical Chemistry, 56: 1667 (1984)]. We also first introduced the use of metal film on nanostructures (MFON), referred to as 'nanowave', as efficient and reproducible plasmonics-active media.

  • Gold Nanostar for Molecular Imaging and Cancer Therapy

    Gold nanostars exhibit a unique star shape and several interesting photonic properties that can be exploited for molecular imaging and cancer therapy. Read more

  • THERANOSTICS: Two-photon Photoluminescence Imaging & Photothermal Therapy

    Two-photon photoluminescence (TPL) imaging offers a strong optical contrast mechanism for viewing Gold Nanostars in real-time. Read more

     

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The Vo-Dinh Lab is a part of the Department of Biomedical Engineering of the Pratt School of Engineering, and the Chemistry Department of the School of Arts & Science,  Duke University. Together with a number of other research groups, the Vo-Dinh Lab is also a part of the Fitzpatrick Institute for Photonics, of which Professor Vo-Dinh is the director.

Holiday Party 2016

The Vo-Dinh Group and family at the 2016 Holiday Party

Research Focus:

Dr. Vo-Dinh’s research activities and interests include the development of advanced technologies and methods in biophotonics, nanophotonics, biosensors, biochips, plasmonics, multi-modality bioimaging, and theranostics (diagnostics and therapy) of diseases such as cancer and infectious diseases.

We have pioneered the development of a new generation of gene probes using surface-enhanced Raman scattering (SERS) detection with ‘Molecular Sentinels’ and Plasmonic Coupling Interference (PCI) molecular probes for multiplex and label-free detection of nucleic acid biomarkers (DNA, mRNA, microRNA) in early detection of cancer. The ability to simultaneously detect multiple oligonucleotide sequences is critical for many medical applications such as early diagnosis, high-throughput screening and systems biology research.

In genomic and precision medicine, nucleic acid-based molecular diagnosis is of paramount importance with many advantages such as high specificity, high sensitivity, serotyping capability, and mutation detection. Using SERS-based plasmonic nanobiosensors and nanochips, we are developing novel nucleic acid detection methods that can be integrated into lab-on-a-chip systems for point-of-care diagnosis  (e.g., breast, GI cancer) and global health applications (e.g., detection of malaria in South East Asia and Africa).

In multi-modality bioimaging, we are developing a novel multifunctional gold nanostar (GNS) probe for use in multi-modality bioimaging in pre-operative scans with PET, MRI and CT, intraoperative margin delineation with optical imaging, SERS and two-photon luminescence (TPL). The GNS can be used also for cancer treatment with plasmonics enhanced photothermal therapy (PTT), thus providing an excellent platform for seamless diagnostics and therapy (i.e., theranostics). Preclinical studies have shown its great potential for cancer diagnostics and therapeutics for future clinical translation.

Various nanobiosensors are being developed for monitoring intracellular parameters (e.g., pH) and biomolecular processes (e.g., apoptosis, caspases), opening the possibility for fundamental molecular biological research as well as biomedical applications (e.g., drug discovery) at the single cell level in a systems biology approach.

The research of the Vo-Dinh Lab is focused on the development of advanced technologies for the protection of the environment and the improvement of human health. The research activities involve biophotonics, nanoplasmonics, nanosensors, laser spectroscopy, molecular imaging, medical diagnostics, cancer detection and therapy, theranostics, chemical sensors, biosensors, and biochips.

Our laboratories are located in the Fitzpatrick Center (FCIEMAS) and the French Family Science Center, both situated on Duke University West Campus.

FCIEMAS

Fitzpatrick Center (FCIEMAS)

 

French

French Family Science Center

summer 2016

The VoDinh Group (Summer 2016)

Group picture 042915

The Vo-Dinh group (Summer 2015)