In 2000, our laboratory developed the first antibody-based nanobiosensor for monitoring biochemical species in a single living human cell [Nature Biotechnology, 18: 764-767 (2000)]. Various nanobiosensors were later developed for monitoring intracellular parameters (e.g., pH) and biomolecular processes (e.g., apoptosis, caspases), opening the possibility for fundamental molecular biological research as well as biomedical applications (e.g., drug discovery) at the single cell level in a systems biology approach.
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- T. Vo-Dinh, A. M. Fales, G.D. Griffin, C. G. Khoury, Y. Liu, H. Ngo, S. J Norton, J. K. Register, H. N. Wang, H. Yuan, “Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy”, Nanoscale, 5, 10127-10140 (2013)
- J. Scaffidi, M. Gregas and T. Vo-Dinh, “SERS-based plasmonic nanobiosensing in single living cells”, Anal. Bioanal. Chem, 393, 1135-1141 (2009)
- PM Kasili, JM Song, T Vo-Dinh, "Optical sensor for the detection of caspase-9 activity in a single cell", Journal of the American Chemical Society 126 (9), 2799-2806 (2004)
- T Vo‐Dinh, "Nanobiosensors: probing the sanctuary of individual living cells", Journal of Cellular Biochemistry 87 (S39), 154-161 (2002)
- BM Cullum, GD Griffin, GH Miller, T Vo-Dinh, "Intracellular measurements in mammary carcinoma cells using fiber-optic nanosensors", Analytical Biochemistry 277 (1), 25-32 (2000)
- T. Vo-Dinh, J. P. Alarie, B. Cullum, and G. D. Griffin, “Antibody-based Nanoprobe for Measurements in a Single Cell”, Nature Biotechnology 18: 764-767 (2000)