In 1994 our laboratory first introduced a new modality for nucleic acid bioassays using surface-enhanced Raman scattering (SERS) detection [Analytical Chemistry, 66, 3379 (1994)]. We further extended the new family of SERS gene probes with the development of ‘Molecular Sentinels’ and Plasmonic Coupling Interference (PCI) molecular probes for multiplex and label-free detection of nucleic acid biomarkers (DNA, mRNA, microRNA). The ability to simultaneously detect multiple oligonucleotide sequences is critical for many medical applications such as early diagnosis, high-throughput screening and systems biology research.
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- H. N. Wang, A. M. Fales, A. K. Zaas, C. W. Woods, T. Burke, G. Ginsburg, T. Vo-Dinh “SERS Molecular Sentinel Nanoprobes for Viral Infection Diagnostics”, Analytica Chimica Acta, 786, 153-158 (2013).
- H.-N. Wang and T. Vo-Dinh, “Plasmonic Coupling Interference (PCI) Nanoprobes for Nucleic Acid Detection”, Small, 7, 3067-3074 (2011)
- T. Vo-Dinh, H. N. Wang and J. Scaffidi “Plasmonic Nanoprobes for SERS Biosensing and Bioimaging”, J. Biophotonics, 3, 89–102 (2010).
- M. Wabuyele and T. Vo-Dinh, “Detection of HIV Type 1 DNA sequence Using Plasmonics Nanoprobes”, Anal. Chem., 77, 7810-7815 (2005).
- T. Vo-Dinh, “Surface-Enhanced Raman Spectroscopy Using Metallic Nanostructures” Trends in Anal. Chem., 17, 557-582 (1998).
- T. Vo-Dinh, K. Houck, and D. L. Stokes, "Surface-Enhanced Raman Gene Probes" Anal. Chem., 66, 3379 (1994).